Fig. 8

Preventive effect of L. sakei powder in a CRKP-infected mice model. A L. sakei powder was administered 3 days before infection and observed for 24 days to investigate the preventive effect of our candidate strain. B Mice were monitored for one week for mortality. C Body weight was checked at 7 days. D Illness severity scores (score parameters: 1, healthy; 2, minimally ill; 3, moderately ill; 4, severely ill; 5, dead) of all mice were measured during probiotic treatment for up to 7 days. Statistical difference in the number of microorganisms from different treatment groups was determined. Significant differences are indicated by asterisks (***p < 0.001; **p < 0.01; *p < 0.05) using unpaired Student’s t-test. A p-value of less than 0.05 was considered statistically significant. All data are presented as mean ± SD