Fig. 7

Prophylactic effect of L. sakei strain in a CRKP-infected mice model. A Candidate probiotic strain L. sakei was administered 3 days before infection to observe its preventive effect during 29 days of the experimental period. B The survival rate of mice was observed for 30 days post-infection. C Body weight was measured for 29 days. D Illness severity scores (score parameters: 1, healthy; 2, minimally ill; 3, moderately ill; 4, severely ill; 5, dead) of all mice were evaluated during 29 days. E The burden of CRKP infection in the stools was significantly reduced, especially on day 8. Significant differences are indicated by asterisks (***p < 0.001; **p < 0.01; *p < 0.05) using unpaired Student’s t-test. A p-value of less than 0.05 was considered statistically significant. All data are presented as mean ± SD