Fig. 6
Two-week repeated oral dose toxicity test of L. sakei. A Guinea pigs in the treatment groups were administered L. sakei orally at 2 × 108 CFU/animal (200 µL per animal) for 14 days, whereas the control group was treated with sterile water. During the experimental period, body weights of all guinea pigs were measured on days 1, 3, 5, 7, 9, 10, and 14. B Mice in treatment groups received L. sakei strain and its powder at a concentration of 3 × 109 CFU/mL through drinking water daily and the single dose administration 3 × 109 CFU/animal (200 µL per animal) once a day using NaCl solution from day 1 to day 14, respectively. In contrast, the control group was treated with sterile water. During the experimental period, the body weights of all mice were measured every 2 days from day 1 to day 10. All data are presented as mean ± SD